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Clinical data | |
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Pronunciation | AR se nik tri OKS id |
Trade names | Trisenox, others |
Other names | Arsenic(III) oxide, Arsenic sesquioxide, Arseneous oxide, Ratsbane, Arseneous anhydride, White arsenic, Aqua Tofani[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a608017 |
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Routes of administration | Intravenous |
Drug class | Antineoplastic agent |
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Pharmacokinetic data | |
Protein binding | 75% |
Excretion | Urine |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.014.075 |
Chemical and physical data | |
Formula | As2O3 |
Molar mass | 197.840 g·mol−1 |
3D model (JSmol) | |
Density | 3.74 g/cm3 |
Melting point | 312.2 °C (594.0 °F) |
Boiling point | 465 °C (869 °F) |
Solubility in water | 20 g/L (25 °C) (see text) |
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ECHA InfoCard | 100.014.075 |
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CompTox Dashboard (EPA)
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GHS labelling:[4] | |
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Danger | |
H300, H314, H350, H410 | |
P201, P202, P260, P264, P270, P273, P280, P301+P330+P331, P303+P361+P353, P304+P340+P310, P305+P351+P338+P310, P308+P313, P363, P391, P405, P501 | |
Safety data sheet (SDS) | american elements SDS |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Arsenic trioxide is an inorganic compound with the formula As
2O
3.[5] As an industrial chemical, its major uses include the manufacture of wood preservatives, pesticides, and glass.[6] It is sold under the brand name Trisenox among others[2][3] when used as a medication to treat a type of cancer known as acute promyelocytic leukemia.[7] For this use it is given by injection into a vein.[7]
Common side effects include vomiting, diarrhea, swelling, shortness of breath, and headaches.[7] Severe side effects may include APL differentiation syndrome and heart problems.[7] Use during pregnancy or breastfeeding may harm the baby.[8][9] Its mechanism in treating cancer is not entirely clear.[7]
Arsenic trioxide was approved for medical use in the United States in 2000.[7] It is on the World Health Organization's List of Essential Medicines.[10] Approximately 50,000 tonnes are produced a year.[11] Due to its toxicity, a number of countries have regulations around its manufacture and sale.[12]